Genome‐wide analysis of the oxyntic proliferative isthmus zone reveals ASPM as a possible gastric stem/progenitor cell marker over‐expressed in cancer
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Genome‐wide analysis of the oxyntic proliferative isthmus zone reveals ASPM as a possible gastric stem/progenitor cell marker over‐expressed in cancer
The oxyntic proliferative isthmus zone contains the main stem/progenitor cells that provide for physiological renewal of the distinct mature cell lineages in the oxyntic epithelium of the stomach. These cells are also proposed to be the potential cells-of-origin of gastric cancer, although little is known about their molecular characteristics and specific biological markers are lacking. In this...
متن کاملControversial role of the possible oxyntic stem cell marker ASPM in gastric cancer.
We read with great interest the article by Vange et al [1] in the December 2015 issue of the Journal of Pathology, as well as the subsequent commentary by Zhu et al in the January 2016 issue [2]. Vange et al identified a novel possible oxyntic stem/progenitor cell marker ASPM [Asp (abnormal spindle) homologue, microcephaly-associated (Drosophila)] by genome-wide expression analysis of the micro...
متن کاملAuthors' reply - Re: Wang et al. Controversial role of the possible oxyntic stem cell marker ASPM in gastric cancer.
We thank Wang et al for their interest in our article ‘Genome-wide analysis of the oxyntic proliferative isthmus zone reveals ASPM as a possible gastric stem/progenitor cell marker over-expressed in cancer’ [1]. In their letter to the editor, ‘Controversial role of the possible oxyntic stem cell marker ASPM in gastric cancer’, Wang et al raise questions about the role of ASPM as a possible nove...
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ژورنال
عنوان ژورنال: The Journal of Pathology
سال: 2015
ISSN: 0022-3417,1096-9896
DOI: 10.1002/path.4591